About one gram of ergot per initiate, processed under the optimal lye conditions of the study published in 2026, would supply the literature minimum effective dose of LSA (about 0.5 mg).

TIK-E008 carries the authors' extrapolation that about 1 g of ergot per initiate could supply an active dose; the arithmetic follows from the reported yield and a literature minimum effective dose of about 0.5 mg. It is an extrapolation from one performance, and a minimum.

Not anchor-only: TIK-E008 on the parent claim records the measured yield (0.54 and 0.48 mg per gram) and the authors' extrapolation that about 1 g per initiate could supply an active dose, and that basis carries the support given. The 0.5 mg minimum-effective-dose threshold is held on the anchor only, and the step is arithmetic on a single performance, not a measurement of effect.

Stoichiometric yields reported by Antonopoulos et al. indicate that one gram of ergot processed under optimal alkaline reflux produces approximately 0.54 mg of LSA and 0.48 mg of iso-LSA, matching the minimum effective human threshold reported in pharmacological literature. The strongest opposing consideration is that ancient ergot batches varied dramatically in alkaloid content and that crude decoctions may exhibit reduced oral bioavailability compared to purified compounds.

The arithmetic is transparent from the measured yield: 0.54 mg LSA per gram of processed ergot meets the 0.5 mg literature minimum effective dose, and the source itself states about 1 g per initiate suffices. The strongest opposing consideration is that the "minimum effective dose" figure is extrapolated from a heterogeneous morning-glory-dominated human literature, not from the reconstructed matrix, so the claim's own hedged framing ("about," "literature minimum") is what the evidence warrants.

TIK-E008 reports 0.54 mg of LSA per gram of ergot and states that the authors extrapolated that about one gram could supply an active dose. The numerical arithmetic therefore supports the claim under the optimal experimental conditions. The strongest opposing consideration is that the literature threshold is not independently audited here, ergot composition can vary, and reaching a nominal minimum dose does not imply reliable or positive psychoactivity.

The 2026 discussion explicitly extrapolates that roughly one gram of ergot processed under optimal lye conditions supplies the literature minimum effective dose of approximately 0.5 mg LSA. The arithmetic follows directly from the measured yields. The strongest opposing consideration is that the minimum-dose figure is taken from external LSA literature (not the reconstructed matrix) and that residual ergometrine and co-products are unprofiled.

E008 reports a yield of 0.54 mg LSA per gram at the optimal condition, against the paper's cited minimum effective dose of about 0.5 mg (per the claim's anchor), so the statement holds as a calculation. It is only provisional for four reasons: no evidence record is formally linked; the margin is under a tenth; the yield comes from a single ergot sample (that field ergot varies in alkaloid content is background, not a ledger measurement; R002); and the dose figure is the authors' citation, unchecked here. Strongest opposing consideration: a minimum effective dose is by definition a threshold, so even an exact figure supports a noticeable effect, not the profound experience C006 requires.

No evidence record of its own. Disclosed basis: the measured yield of about 0.54 mg LSA per gram in TIK-E008, attached to TIK-C005, the claim this step builds on. The 0.5 mg threshold is cited from literature not checked here. The step is therefore weakly supported, and it names a minimum, not a reliable dose.