The Religion with No Name · source record · paper

Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials

Castro, P. S. C. C.; Leopoldo, K.; Pedro, M. O. P.; Takitane, J.; Bombana, H. S.; Negrão, A. B.; Scholz, J. R.; Castaldelli-Maia, J. M. · 2025

AI-verified citationSRC-CASTRO-2025

identifier / locator: Pharmacy (Basel) 13(4): 98 (2025-07-21). DOI: 10.3390/pharmacy13040098. PMC12286086
url: https://doi.org/10.3390/pharmacy13040098
verification note: Title, journal, volume/issue, date, DOI, and author list verified via NCBI PMC metadata (2026-08-25 batch); full text not re-read at import (PMC blocked automated access), characterization follows the abstract and the intake brief's reading, cross-checked against the record.
reliability notes: The systematic review used here to keep 'LSA was produced' from silently becoming 'an LSD-like experience would predictably result': LSA is psychoactive but weaker and messier than LSD, with prominent nausea, autonomic effects, and occasional severe adverse outcomes.

Evidence drawn from this source

Qualifies· moderateTIK-E012

what the source states: The 2025 systematic review characterizes lysergic acid amide (LSA) as a psychoactive LSD analog with documented hallucinations and euphoria, alongside prominent adverse outcomes in the human literature — nausea, autonomic and vegetative effects, anxiety, and occasional severe psychiatric or cardiovascular events — and substantially lower potency than LSD.
what we infer: Keeps the pharmacological gap open and honest: "LSA was produced" does not become "an LSD-like mystical experience would predictably result." Four separable propositions — LSA reaches the brain, is psychoactive, can hallucinate, and reliably yields a profound positive experience at achievable doses — have support that stops at the third.
limitations: Human data are dominated by morning-glory-seed exposures, not lye-processed ergot extracts; the reconstructed preparation itself has never been profiled (TIK-R003).