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Experimental indications of non-classical brain functions

Kerskens, Christian Matthias; López Pérez, David · 2022

AI-verified citationSRC-KERSKENS-2022
identifier / locator
Journal of Physics Communications 6(10): 105001. DOI: 10.1088/2399-6528/ac94be
url
https://doi.org/10.1088/2399-6528/ac94be
verification note
Verified via Crossref (2026-08-22 run); full abstract read directly. The authors' own conclusion is quoted verbatim on the evidence record rather than paraphrased, because the strength of their hedging ("suggest that we may have witnessed") is itself contested in secondary discussion.
reliability notes
  • A real measurement in living human brains using a zero-quantum-coherence protocol designed to suppress conventional MRI contrast — genuinely novel, and the signal's dependence on conscious awareness is the striking part.
  • Says nothing about microtubules. The proposed mediator is unidentified; proton spins of bulk water are the known systems.
  • Contested in the same journal (SRC-WARREN-2023), with an authors' reply (DOI 10.1088/2399-6528/acc636, verified via Crossref). No independent exact replication identified.

Evidence drawn from this source

Supports· moderateORCH-E020

Consciousness-dependent zero-quantum-coherence signals in living human brains

what the source states
The authors report using a zero-quantum-coherence MRI protocol, derived from proposals for witnessing quantum gravity, in which detected signals should not arise from classical sources. They observed heartbeat-evoked potential-like signals in living human brains that did not correlate with any conventional MRI contrast, and which changed in relation to conscious awareness — subjects reported the signal disappearing as they fell asleep. The abstract concludes: "Our findings suggest that we may have witnessed entanglement mediated by consciousness-related brain functions. Those brain functions must then operate non-classically, which would mean that consciousness is non-classical."
what we infer
The single most consequential result in this case if it survives — direct evidence of non-classical function in a living brain would be a landmark independent of Orch OR. Two things restrain the weight given here. It is contested on methodological grounds by a leading NMR authority (ORCH-E021) and has not been independently replicated. And its scope is narrower than proponent summaries suggest: the experiment does not implicate microtubules at all, the mediator is unidentified, and the known quantum systems in the measurement are proton spins of bulk water. A fully validated result would establish non-classical brain function while leaving every microtubule claim untouched.
limitations
  • Entanglement-witness interpretation disputed in the same journal; no independent replication.
  • Mediating system unidentified; microtubules not implicated by the experiment.
  • Small sample; consciousness manipulation was naturalistic sleep onset rather than a controlled intervention.
  • The authors' own wording is heavily hedged ('suggest that we may have witnessed'), and secondary summaries frequently drop the hedge.