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State, Not Scar · source record · paper

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

Jammal Salameh, L.; Bitzenhofer, S. H.; Hanganu-Opatz, I. L.; Dutschmann, M.; Egger, V. · 2024

AI-verified citationSRC-SALAMEH-2024
identifier / locator
Science 383(6682). DOI: 10.1126/science.adk8511
verification note
Confirmed via Crossref (2026-08-22 batch). Imported from the critical report, which cites it as "Salameh AI"; the registered first author is Jammal Salameh, Luna.
reliability notes
  • Rat preparations and awake animals; brain tissue, not peripheral tender points; demonstrates fast mechanosensitive modulation, not stored information.

Evidence drawn from this source

Supports· strongVASO-E005

Blood-pressure pulsations modulate neurons via mechanosensitive channels

what the source states
Physiological blood-pressure pulsations were shown to modulate central neuronal activity through mechanosensitive ion channels in rat preparations and awake animals, on rapid timescales.
what we infer
Direct causal evidence for the vascular-mechanical-to-neural direction the hemo-neural hypothesis requires — sixteen years after it was proposed, the read path has a demonstrated mechanism.
limitations
  • Rat brain, not human periphery; demonstrates instantaneous mechanosensation, not storage or content-specific readout.