Supports· moderateVASO-E006
Acidic, mediator-rich biochemical milieu at active trigger points
- what the source states
- Microdialysis-style sampling found biochemicals associated with pain and inflammation — including bradykinin, substance P, and CGRP, in a more acidic milieu — elevated at active myofascial trigger points, in sites both near to and remote from the points, relative to comparison conditions.
- what we infer
- Something is there and it is chemically angry — exactly the milieu chronic local ischemia would produce, though guarding-induced compression would produce it too. Note the title's own qualifier: the elevation was not purely local.
- limitations
- Small study (the critical report's audit gives nine volunteers); localization vs systemic effects hard to separate.