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Radical pairs may play a role in xenon-induced general anesthesia

Jordan Smith; Hadi Zadeh-Haghighi; Dennis Salahub; Christoph Simon · 2021

AI-verified citationSRC-SMITH-2021
identifier / locator
doi:10.1038/s41598-021-85673-w
url
https://www.nature.com/articles/s41598-021-85673-w
verification note
text retrieved and shown to the drafter on 2026-09-11 (run 2026-09-11-draft-orch-or-115454); passages checked by the verify verb
reliability notes
  • Peer-reviewed, Scientific Reports 11:6287.
  • Text read via the open-access author copy at arxiv.org/pdf/2009.01661 (arXiv:2009.01661v2); page locators refer to that PDF.
  • Modelling paper: reproduces the published Li et al. 2018 per-isotope potencies within a radical-pair framework; it does not report new in vivo measurements.

Evidence drawn from this source

Context· weakORCH-E042

The four published per-isotope xenon potencies, independently restated

what the source states
The authors quote the loss-of-righting-reflex ED50 values reported by Li et al. for 132Xe, 134Xe, 131Xe and 129Xe "to be 70(4)%, 72(5)%, 99(5)%, and 105(7)%, respectively", and derive relative potencies of 1, 0.71(8) and 0.67(8) for spin-0, spin-3/2 and spin-1/2 xenon.
what we infer
This is a second party's extraction of the same four numbers the case's own workpaper (ORCH-E040) flags as calculated rather than measured; it cross-checks the extraction but adds no independent measurement, so its diagnosticity for the underlying observation is near zero.
limitations
  • Purely a restatement of SRC-LI-2018; not a replication.
  • The dispersions carried over are of the same unstated type recorded at ORCH-E040.
  • Direction set to "context" (from "supports") by the second reader (claude-sonnet-5, 2026-09-11, run 2026-09-11-verify-orch-or-120610, verify-v6) at intake: The quoted numbers are accurate and correctly located, and the record itself acknowledges this is merely a restatement of Li et al.'s data rather than an independent finding of Smith et al. Per the rule that a citation or restatement of another (unretrieved) study's findings is not itself evidence of what that study found, this passage should be marked as context on ORCH-C025 rather than as support, despite the data being consistent with the claim.
Jordan Smith (2021)AI-verified citationORCH-C025