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Importance of quantum decoherence in brain processes

Tegmark, Max · 2000

AI-verified citationSRC-TEGMARK-2000
identifier / locator
Physical Review E 61(4): 4194–4206. DOI: 10.1103/PhysRevE.61.4194
url
https://doi.org/10.1103/PhysRevE.61.4194
verification note
Verified via Crossref and PubMed (PMID 11088215); abstract read directly (2026-08-22 run). The decoherence range 10⁻¹³–10⁻²⁰ s and the comparison dynamical timescales 10⁻³–10⁻¹ s are quoted from the abstract.
reliability notes
  • The canonical skeptical citation, and for twenty-five years the reason most neuroscientists considered the question closed.
  • A calculation, not a measurement — and explicitly a calculation about particular modeled superpositions (charge separations, soliton-like microtubule excitations), which is the basis of the Hagan reply.
  • Eugene's primer says Tegmark 'incorrectly assumed thermal equilibrium — i.e. a dead brain.' That is a proponent characterization (via Wiest), sharper than the exchange in the published record; the specific objections Hagan et al. actually raised are recorded on the evidence record.

Evidence drawn from this source

Undermines· moderateORCH-E007

Tegmark: microtubule decoherence 10⁻¹³–10⁻²⁰ s, far too fast for neural relevance

what the source states
The abstract reports calculated decoherence timescales for superposed neural states — specifically "for superpositions of neuron firing (coherent or not)" and "for either separated coherent states of a single tubulin or for two tubulins in the same state" — in the range 10⁻¹³ to 10⁻²⁰ seconds, against dynamical timescales of neural processes of 10⁻³ to 10⁻¹ seconds. The conclusion drawn is that "the degrees of freedom of the human brain that relate to cognitive processes should be thought of as a classical rather than quantum system."
what we infer
For twenty-five years this has been the reason most neuroscientists considered the question closed, and the gap it reports — ten to seventeen orders of magnitude — is large enough that no amount of refinement at the margins would close it. Its evidential status should be stated plainly though: it is a calculation about a modeled state, not a measurement of a microtubule, and its force depends entirely on whether the state it modeled is the state the theory proposes. That is precisely what the Hagan reply contests, which is why this is graded moderate rather than strong.
limitations
  • A theoretical calculation, not a measurement; no microtubule was observed.
  • Models specific superposed states whose correspondence to the Orch OR proposal is disputed by Hagan et al. 2002.
  • Predates the ordered-lattice and collective-state work of 2023–2024, which changes some of the assumed environment.
  • Assumes environmental coupling parameters that the proponent reply argues are inappropriate for ordered biological structures.